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1

Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model

Li, Jason, Chu, Michael K.L., Gordijo, Claudia R., Abbasi, Azhar Z., Chen, Kuan, Adissu, Hibret A., Löhn, Matthias, Giacca, Adria, Plettenburg, Oliver, Wu, Xiao Yu

Journal:

Year:

2015

Language:

english

File:

PDF, 4.70 MB

english, 2015

2

Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices

Li, Jason, Chu, Michael K., Lu, Brian, Mirzaie, Sako, Chen, Kuan, Gordijo, Claudia R., Plettenburg, Oliver, Giacca, Adria, Wu, Xiao Yu

Journal:

Drug Delivery and Translational Research

Year:

2017

Language:

english

File:

PDF, 2.79 MB

english, 2017

3

A monolithic polymeric microdevice for pH-responsive drug delivery

Jian Chen, Michael Chu, Khajag Koulajian, Xiao Yu Wu, Adria Giacca, Yu Sun

Journal:

Biomedical Microdevices

Year:

2009

Language:

english

File:

PDF, 416 KB

english, 2009

4

Acute Effects of Single-Dose Olanzapine on Metabolic, Endocrine, and Inflammatory Markers in Healthy Controls

Hahn, Margaret Karolina, Wolever, Tom M.S., Arenovich, Tamara, Teo, Celine, Giacca, Adria, Powell, Valerie, Clarke, Leigh, Fletcher, Paul, Cohn, Tony, McIntyre, Roger S., Gomes, Sylvia, Chintoh, Araba

Journal:

Journal of Clinical Psychopharmacology

Year:

2013

Language:

english

File:

PDF, 394 KB

english, 2013

5

High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis

Guo, June, Pereira, Troy J., Dalvi, Prasad, Yeung, Lucy Shu Nga, Swain, Nathan, Breen, Danna M., Lam, Loretta, Dolinsky, Vernon W., Giacca, Adria

Journal:

Year:

2017

Language:

english

File:

PDF, 892 KB

english, 2017

6

In male rats, the ability of central insulin to suppress glucose production is impaired by olanzapine, whereas glucose uptake is left intact

Kowalchuk, Chantel, Teo, Celine, Wilson, Virginia, Chintoh, Araba, Lam, Loretta, Agarwal, Sri Mahavir, Giacca, Adria, Remington, Gary J., Hahn, Margaret K.

Journal:

Journal of Psychiatry and Neuroscience

Year:

2017

Language:

english

File:

PDF, 285 KB

english, 2017

7

Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo

Desai, Tejas, Koulajian, Khajag, Ivovic, Aleksandar, Breen, Danna M., Luu, Lemieux, Tsiani, Evangelia L., Wheeler, Michael B., Giacca, Adria

Journal:

Nutrition and Diabetes

Year:

2019

Language:

english

File:

PDF, 1.25 MB

english, 2019

8

In vitro and in vivo testing of glucose-responsive insulin-delivery microdevices in diabetic rats

Chu, Michael K. L., Chen, Jian, Gordijo, Claudia R., Chiang, Simon, Ivovic, Alexander, Koulajian, Khajag, Giacca, Adria, Wu, Xiao Yu, Sun, Yu

Journal:

Year:

2012

Language:

english

File:

PDF, 693 KB

english, 2012

9

Insulin Inhibits and Oral Sucrose Increases Neointimal Growth after Arterial Injury in Rats

Breen, Danna M., Dhaliwall, Jiwanjeet K., Chan, Kalam K., Guo, June, Lam, Loretta, Bendeck, Michelle P., Giacca, Adria

Journal:

Journal of Vascular Research

Year:

2010

Language:

english

File:

PDF, 346 KB

english, 2010

10

NOD1: An Interface Between Innate Immunity and Insulin Resistance

Rivers, Sydney L, Klip, Amira, Giacca, Adria

Journal:

Year:

2019

File:

PDF, 603 KB

2019

11

Plasma Nonesterified Fatty Acid Intolerance and Hyperglycemia Are Associated with Intravenous Lipid-Induced Impairment of Insulin Sensitivity and Disposition Index

Carpentier, André C., Bourbonnais, Annie, Frisch, Frédérique, Giacca, Adria, Lewis, Gary F.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2010

Language:

english

File:

PDF, 133 KB

english, 2010

12

The Diabetogenic Effects of Glucocorticoids are More Pronounced in Low-Than in High-Insulin Responders

Alexandre Wajngot, Adria Giacca, Valdemar Grill, Mladen Vranic and Suad Efendic

Journal:

Proceedings of the National Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 827 KB

english, 1992

13

Direct and Indirect Effects of Insulin in Suppressing Glucose Production in Depancreatized Dogs: Role of Glucagon 1

Giacca, Adria, Fisher, Simon J., McCall, Richard H., Shi, Z. Qing, Vranic, Mladen

Journal:

Year:

1997

Language:

english

File:

PDF, 380 KB

english, 1997

14

A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp

Simon J. Fisher, Zhi Q. Shi, H.Lavina A. Lickley, Suad Efendic, Mladen Vranic, Adria Giacca

Journal:

Year:

1996

Language:

english

File:

PDF, 719 KB

english, 1996

15

Increased responses of glucagon and glucose production to hypoglycemia with intraperitoneal versus subcutaneous insulin treatment

Calvin K.N. Wan, Adria Giacca, Munehide Matsuhisa, Ban El-Bahrani, Loretta Lam, Carol Rodgers, Z.Qing Shi

Journal:

Year:

2000

Language:

english

File:

PDF, 60 KB

english, 2000

16

Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo

Pereira, Sandra, Park, Edward, Moore, Jessy, Faubert, Brandon, Breen, Danna M., Oprescu, Andrei I., Nahle, Ashraf, Kwan, Denise, Giacca, Adria, Tsiani, Evangelia

Journal:

Applied Physiology Nutrition and Metabolism

Year:

2015

File:

PDF, 918 KB

2015

17

Antipsychotics and glucose metabolism: how brain and body collide

Kowalchuk, Chantel, Castellani, Laura, Chintoh, Araba, Remington, Gary, Giacca, Adria, Hahn, Margaret

Journal:

American Journal of Physiology-Endocrinology and Metabolism

Year:

2018

Language:

english

File:

PDF, 1.64 MB

english, 2018

18

52. Antipsychotics Perturb Glucose Homeostasis by Inhibiting Hypothalamic KATP Channel Activation

Kowalchuk, Chantel, Castellani, Laura, Teo, Celine, Kanagasundaram, Pruntha, McIntyre, William Brett, Remington, Gary, Giacca, Adria, Hahn, Margaret

Journal:

Biological Psychiatry

Year:

2019

Language:

english

File:

PDF, 67 KB

english, 2019

19

Amelioration of High-Insulin-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol Is Linked to Activation of AMPK and Restoration of GLUT4 Translocation

Vlavcheski, Filip, Den Hartogh, Danja J., Giacca, Adria, Tsiani, Evangelia

Journal:

Year:

2020

File:

PDF, 3.57 MB

2020

20

Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites

Lam, Tony K. T., Van de Werve, Gérald, Giacca, Adria

Journal:

American Journal of Physiology-Endocrinology and Metabolism

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

21

Nanotechnology-Enabled Closed Loop Insulin Delivery Device: In Vitro and In Vivo Evaluation of Glucose-Regulated Insulin Release for Diabetes Control

Claudia R. Gordijo, Khajag Koulajian, Adam J. Shuhendler, Leonardo D. Bonifacio, Hui Yu Huang, Simon Chiang, Geoffrey A. Ozin, Adria Giacca, Xiao Yu Wu

Journal:

Advanced Functional Materials

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

22

Effects of Insulin on the Vasculature

M. Breen, Danna, Giacca, Adria

Journal:

Current Vascular Pharmacology

Year:

2011

Language:

english

File:

PDF, 255 KB

english, 2011

23

Longitudinal Associations of Phospholipid and Cholesteryl Ester Fatty Acids With Disorders Underlying Diabetes

Johnston, Luke W., Harris, Stewart B., Retnakaran, Ravi, Zinman, Bernard, Giacca, Adria, Liu, Zhen, Bazinet, Richard P., Hanley, Anthony J.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2016

Language:

english

File:

PDF, 779 KB

english, 2016

24

Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: An animal model

Margaret Hahn, Araba Chintoh, Adria Giacca, Li Xu, Loretta Lam, Steve Mann, Paul Fletcher, Melanie Guenette, Tony Cohn, Tom Wolever, Tamara Arenovich, Gary Remington

Journal:

Schizophrenia Research

Year:

2011

Language:

english

File:

PDF, 591 KB

english, 2011

25

Chronic olanzapine administration in rats: Effect of route of administration on weight, food intake and body composition

Mann, Steve, Chintoh, Araba, Giacca, Adria, Fletcher, Paul, Nobrega, Jose, Hahn, Margaret, Remington, Gary

Journal:

Pharmacology Biochemistry and Behavior

Year:

2013

Language:

english

File:

PDF, 376 KB

english, 2013

26

The Hyperglycemia-induced Inflammatory Response in Adipocytes

Lin, Ying, Berg, Anders H., Iyengar, Puneeth, Lam, Tony K. T., Giacca, Adria, Combs, Terry P., Rajala, Michael W., Du, Xueliang, Rollman, Brent, Li, Weijie, Hawkins, Meredith, Barzilai, Nir, Rhodes, C

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 1.08 MB

english, 2005

27

[IEEE TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference - Denver, CO, USA (2009.06.21-2009.06.25)] TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference - pH-responsive drug-delivery devices for implantable applications

Chen, Jian, Chu, Michael, Koulajian, Khajag, Wu, Xiao Yu, Giacca, Adria, Sun, Yu

Year:

2009

Language:

english

File:

PDF, 465 KB

english, 2009

28

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-δ

Lam, Tony K. T., Yoshii, Hidenori, Haber, C. Andrew, Bogdanovic, Elena, Lam, Loretta, Fantus, I. George, Giacca, Adria

Journal:

AJP Endocrinology and Metabolism

Year:

2002

Language:

english

File:

PDF, 299 KB

english, 2002

29

The Effect of Resveratrol on Reducing Neointimal Growth after Femoral Artery Injury is Abolished in AMPKα2 Knock-out Mice

Zhou, Liwei, Guo, June, Zhang, Hangjun, Heximer, Scott, Giacca, Adria

Journal:

Atherosclerosis Supplements

Year:

2018

Language:

english

File:

PDF, 390 KB

english, 2018

30

Attenuation of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTOR and p70 S6K

Den Hartogh, Danja J., Vlavcheski, Filip, Giacca, Adria, Tsiani, Evangelia

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 4.66 MB

2020

31

Anti-Atherogenic Effect of Insulin in vivo

Kim, Tony, Chan, Kalam K., Dhaliwall, Jiwanjeet K., Huynh, Nghia, Suen, Renee, Uchino, Hiroshi, Naigamwalla, Dinaz, Bendeck, Michelle P., Giacca, Adria

Journal:

Journal of Vascular Research

Year:

2005

Language:

english

File:

PDF, 236 KB

english, 2005

32

Hyperinsulinemia, insulin resistance and free fatty acids. The dog model in diabetes and obesity research

Giacca, Adria, Wiesenthal, Stephanie, Sandhu, Harmanjit, McCall, Richard, Tchipachvili, Vaja, Rashid, Shirya, Lewis, Gary, Shi, Zhi Qing, Vranic, Mladen, Efendic, Suad

Journal:

Experimental and Clinical Endocrinology & Diabetes

Year:

1997

Language:

english

File:

PDF, 15 KB

english, 1997

33

Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ

Lu, Huogen, Bogdanovic, Elena, Yu, Zhiwen, Cho, Charles, Liu, Lijiang, Ho, Karen, Guo, June, Yeung, Lucy S N, Lehmann, Reiner, Hundal, Harinder S, Giacca, Adria, Fantus, I George

Journal:

Year:

2018

Language:

english

File:

PDF, 2.17 MB

english, 2018

34

NOD1: An Interface Between Innate Immunity and Insulin Resistance

Rivers, Sydney L, Klip, Amira, Giacca, Adria

Journal:

Year:

2019

Language:

english

File:

PDF, 603 KB

english, 2019

35

Glucose Regulation by Modified Boronic Acid-Sulfobetaine Zwitterionic Nanogels - A Non-Hormonal Strategy for the Potential Treatment of Hyperglycemia

GhavamiNejad, Amin, Lu, Brian, Giacca, Adria, Wu, Xiao Yu

Journal:

Year:

2019

Language:

english

File:

PDF, 961 KB

english, 2019

36

Poster #223 SINGLE DOSE ADMINISTRATION OF OLANZAPINE: EFFECTS ON GLUCOSE METABOLISM, ENDOCRINE AND INFLAMMATORY MARKERS IN HEALTHY VOLUNTEERS

Margaret K. Hahn, Tamara Arenovich, Tom Wolever, Adria Giacca, Tony Cohn, Roger McIntyre, Celine Teo, Leigh Clarke, Valerie Powell, Araba Chintoh, Steve Mann, Sylvia Gomes, Gary Remington

Journal:

Schizophrenia Research

Year:

2012

Language:

english

File:

PDF, 70 KB

english, 2012

37

Hyperinsulinemia, But Not Other Factors Associated with Insulin Resistance, Acutely Enhances Colorectal Epithelial Proliferation in Vivo

Tran, Thien T., Naigamwalla, Dinaz, Oprescu, Andrei I., Lam, Loretta, McKeown-Eyssen, Gail, Bruce, W. Robert, Giacca, Adria

Journal:

Year:

2006

Language:

english

File:

PDF, 398 KB

english, 2006

38

61. Olanzapine Inhibits Central Insulin Action Resulting in Glucose Dysregulation

Kowalchuk, Chantel, Teo, Celine, Wilson, Virginia, Giacca, Adria, Remington, Gary, Hahn, Margaret

Journal:

Biological Psychiatry

Year:

2017

Language:

english

File:

PDF, 60 KB

english, 2017

39

Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK

Danna M. Breen, Toran Sanli, Adria Giacca, Evangelia Tsiani

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 301 KB

english, 2008

40

Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes

Johnston, Luke W., Liu, Zhen, Retnakaran, Ravi, Zinman, Bernard, Giacca, Adria, Harris, Stewart B., Bazinet, Richard P., Hanley, Anthony J.

Journal:

The Journal of Lipid Research

Year:

2018

Language:

english

File:

PDF, 1.76 MB

english, 2018

41

In Vivo Performance and Biocompatibility of a Subcutaneous Implant for Real-Time Glucose-Responsive Insulin Delivery

Chu, Michael K.L., Gordijo, Claudia R., Li, Jason, Abbasi, Azhar Z., Giacca, Adria, Plettenburg, Oliver, Wu, Xiao Yu

Journal:

Diabetes Technology & Therapeutics

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

42

Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings

Yang, Kai, Fard, Sara, Furrer, Rudolf, Archer, Michael C., Bruce, W. Robert, Lip, HoYin, Mehta, Rhea, O'Brien, Peter J., Giacca, Adria, Ward, Wendy E., Femia, A. Pietro, Caderni, Giovanna, Medline, Al

Journal:

Nutrition and Cancer

Year:

2016

Language:

english

File:

PDF, 817 KB

english, 2016

43

259. Olanzapine Impairs Central Insulin Action: Effects on Body Fuel Preference

Castellani, Laura, Wilkin, Jennifer, Ahsan, Zohra, Kowalchuk, Chantel, Teo, Celine, Giacca, Adria, Wright, David, Remington, Gary, Hahn, Margaret

Journal:

Biological Psychiatry

Year:

2018

Language:

english

File:

PDF, 44 KB

english, 2018

44

O9.2. ANTIPSYCHOTIC DRUGS IMPAIR BRAIN GLUCOSE SENSING RESULTING IN WHOLE BODY INSULIN RESISTANCE

Castellani, Laura, Kowalchuk, Chantel, Asgariroozbehani, Roshanak, Tran, Veronica, Brett McIntyre, William, Hamel, Laurie, Remington, Gary, Giacca, Adria, Hahn, Margaret

Journal:

Schizophrenia Bulletin

Year:

2020

File:

PDF, 76 KB

2020

45

CLINCIAL INSIGHTS DERIVED FROM RODENT MODELS OF ANTIPSYCHOTIC-INDUCED METABOLIC PERTRUBATIONS

Hahn, Margaret K., Remington, Gary, Chintoh, Araba, Teo, Celine, Fletcher, Paul, Norbrega, Jose, Guenette, Melanie, Cohn, Tony, Giacca, Adria

Journal:

Schizophrenia Research

Year:

2014

Language:

english

File:

PDF, 87 KB

english, 2014

46

Proceedings of a Symposium to Honour Mladen Vranic for a Lifetime of Scientific Achievements and Mentoring

Brubaker, Patricia L., Cherrington, Alan D., Finegood, Diane T., Fisher, Simon J., Giacca, Adria, Marette, Andre, Riddell, Michael C., Wasserman, David H.

Journal:

Canadian Journal of Diabetes

Year:

2010

Language:

english

File:

PDF, 807 KB

english, 2010

47

Acute Dipeptidyl Peptidase-4 Inhibition Rapidly Enhances Insulin-Mediated Suppression of Endogenous Glucose Production in Mice

Duez, Hélène, Smith, Angela C., Xiao, C., Giacca, Adria, Szeto, Linda, Drucker, Daniel J., Lewis, Gary F.

Journal:

Year:

2009

Language:

english

File:

PDF, 193 KB

english, 2009

48

Mechanisms underlying fat-induced hepatic insulin resistance

Park, Edward, Giacca, Adria

Journal:

Future Lipidology

Year:

2007

Language:

english

File:

PDF, 1.04 MB

english, 2007

49

Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease

Lino, Marsel, Ngai, David, Liu, Alison, Mohabeer, Amanda, Harper, Cameron, Caruso, Laura-lee, Schroer, Stephanie A., Fu, Fred, McKee, Trevor, Giacca, Adria, Woo, Minna, Bendeck, Michelle P.

Journal:

Molecular Metabolism

Year:

2020

File:

PDF, 3.47 MB

2020

50

In vivo Effect of Insulin to Decrease Matrix Metalloproteinase-2 and -9 Activity after Arterial Injury

Guo, June, Dhaliwall, Jiwanjeet K., Chan, Kalam K., Ghanim, Husam, Al Koudsi, Nael, Lam, Loretta, Madadi, Golnaz, Dandona, Paresh, Giacca, Adria, Bendeck, Michelle P.

Journal:

Journal of Vascular Research

Year:

2013

Language:

english

File:

PDF, 309 KB

english, 2013

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